This paper illustrates our approach to the shared task on large-scale multilingual machine translation in the sixth conference on machine translation (WMT-21). In this work, we aim to build a single multilingual translation system with a hypothesis that a universal cross-language representation leads to better multilingual translation performance. We extend the exploration of different back-translation methods from bilingual translation to multilingual translation. Better performance is obtained by the constrained sampling method, which is different from the finding of the bilingual translation. Besides, we also explore the effect of vocabularies and the amount of synthetic data. Surprisingly, the smaller size of vocabularies perform better, and the extensive monolingual English data offers a modest improvement. We submitted to both the small tasks and achieve the second place.