This paper presents the submission of Huawei Translate Services Center (HW-TSC) to the WMT 2021 News Translation Shared Task. We participate in 7 language pairs, including Zh/En, De/En, Ja/En, Ha/En, Is/En, Hi/Bn, and Xh/Zu in both directions under the constrained condition. We use Transformer architecture and obtain the best performance via multiple variants with larger parameter sizes. We perform detailed pre-processing and filtering on the provided large-scale bilingual and monolingual datasets. Several commonly used strategies are used to train our models, such as Back Translation, Forward Translation, Multilingual Translation, Ensemble Knowledge Distillation, etc. Our submission obtains competitive results in the final evaluation.