In this paper, we describe our MiSS system that participated in the WMT21 news translation task. We mainly participated in the evaluation of the three translation directions of English-Chinese and Japanese-English translation tasks. In the systems submitted, we primarily considered wider networks, deeper networks, relative positional encoding, and dynamic convolutional networks in terms of model structure, while in terms of training, we investigated contrastive learning-reinforced domain adaptation, self-supervised training, and optimization objective switching training methods. According to the final evaluation results, a deeper, wider, and stronger network can improve translation performance in general, yet our data domain adaption method can improve performance even more. In addition, we found that switching to the use of our proposed objective during the finetune phase using relatively small domain-related data can effectively improve the stability of the model's convergence and achieve better optimal performance.