Effects of in-medium cross-sections and of optical potential on pre-equilibrium emission and on formation of a thermal source are investigated by comparing the results of transport simulations with experimental results from the p+{197}Au reaction at 6.2-14.6 GeV/c. The employed transport model includes light composite-particle production and allows for inclusion of in-medium particle-particle cross-section reduction and of momentum dependence in the particle optical-potentials. Compared to the past, the model incorporates improved parameterizations of elementary high-energy processes. The simulations indicate that the majority of energy deposition occurs during the first ~25 fm/c of a reaction. This is followed by a pre-equilibrium emission and readjustment of system density and momentum distribution toward an equilibrated system. Good agreement with data, on the d/p and t/p yield ratios and on the residue mass and charge numbers, is obtained at the time of ~ 65 fm/c from the start of a reaction, provided reduced in-medium cross-sections and momentum-dependent optical potentials are employed in the simulations. By then, the pre-equilibrium nucleon and cluster emission, as well as mean-field readjustments, drive the system to a state of depleted average density, rho/rho_{0} ~ 1/4-1/3 for central collisions, and low-to-moderate excitation, i.e. the region of nuclear liquid-gas phase transition.
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