We investigate the structure of the Schrodinger algebra and its representations in a Fock space realized in terms of canonical Appell systems. Generalized coherent states are used in the construction of a Hilbert space of functions on which certain commuting elements act as self-adjoint operators. This yields a probabilistic interpretation of these operators as random variables. An interesting feature is how the structure of the Lie algebra is reflected in the probability density function. A Leibniz function and orthogonal basis for the Hilbert space is found. Then Appell systems connected with certain evolution equations, analogs of the classical heat equation, on this algebra are computed.