In this talk I give a preliminary account of original results, obtained in collaboration with John Ellis. Details and further elaboration will be presented in a forthcoming publication. We present a proposal for a non-critical (Liouville) string approach to confinement of four-dimensional (non-abelian) gauge theories, based on recent developments on the subject by Witten and Maldacena. We discuss the effects of vortices and monopoles on the open world-sheets whose boundaries are Wilson loops of the target-space (non Abelian) Gauge theory. By appropriately employing `D-particles, associated with the target-space embedding of such defects, we argue that the apprearance of five-dimensional Anti-De-Sitter (AdS) space times is quite natural, as a result of Liouville dressing.We isolate the world-sheet defect contributions to the Wilson loop by constructing an appropriate observable, which is the same as the second observable in the supersymmetric U(1) theory of Awada and Mansouri, but in our approach supersymmetry is not necessary.When vortex condensation occurs, we argue in favour of a (low-temperature) confining phase, in the sense of an area law, for a large-$N_c$ (conformal) gauge theory at finite temperatures. A connection of the Berezinski-Kosterlitz-Thouless (BKT) transitions on the world-sheet with the critical temperatures in the thermodynamics of Black Holes in the five-dimensional AdS space is made.