We show that Calabi-Yau crystals generate certain Chern-Simons knot invariants, with Lagrangian brane insertions generating the unknot and Hopf link invariants. Further, we make the connection of the crystal brane amplitudes to the topological vertex formulation explicit and show that the crystal naturally resums the corresponding topological vertex amplitudes. We also discuss the conifold and double wall crystal model in this context. The results suggest that the free energy associated to the crystal brane amplitudes can be simply expressed as a target space Gopakumar-Vafa expansion.