We study QED corrections to the chiral symmetry breaking in Nambu-Jona-Lasinio (NJL) model with two flavors of quarks. In the model the isospin symmetry is broken by differences of the current quark masses and the electromagnetic charges between up and down quarks. In the leading order of the 1/N expansion we calculate the effective potential of the model with one-loop QED corrections. Evaluating the effective potential, we study an influence of the isospin symmetry breaking on the orientation of chiral symmetry breaking. The current quark mass has an important contribution for the orientation of chiral symmetry breaking.