We review the hadro-production data presently available on open charm and beauty absolute production cross-sections, collected by experiments at CERN, DESY and Fermilab. The published charm production cross-section values are updated, in particular for the time evolution of the branching ratios. These measurements are compared to LO pQCD calculations, as a function of the collision energy, using recent parametrisations of the parton distribution functions. We then estimate, including nuclear effects of the parton densities, the charm and beauty production cross-sections relevant for measurements at SPS and RHIC energies, in proton-proton, proton-nucleus and nucleus-nucleus collisions. The calculations are also compared with measurements of single D and B kinematical distributions, and DDbar pair correlations. We finish with two brief comments, concerning the importance of beauty production as a feed-down source of J/psi production, and open charm measurements performed using leptonic decays.
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