Lorentz and CPT tests involving matter-antimatter comparisons at low temperatures are discussed. SME predictions for transition frequencies in such systems include both matter-antimatter differences and sidereal variations. In hydrogen-antihydrogen spectroscopy, leading-order effects in a 1S-2S transition as well as in a 1S Zeeman transition could exist that can be employed to obtain clean constraints. Similarly, tight bounds can be determined from Penning-trap experiments involving antiprotons.
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