Using the method of QCD light-cone sum rules, we calculate the $B to pipi$ hadronic matrix elements with annihilation topology. We obtain a finite result, including the related strong phase. Numerically, the annihilation effects in $Bto pipi$ turn out to be small with respect to the factorizable emission mechanism. Our predictions, together with the earlier sum rule estimates of emission and penguin contributions, are used for the phenomenological analysis of $Bto pipi$ channels. We predict a $Delta I=1/2$ transition amplitude which significantly differs from this amplitude extracted from the current data.