The effect of changes in hadron properties in a nuclear medium on physical observables is discussed. Highlighted results are, (1) hypernuclei, (2) meosn-nuclear bound states, (3) $K$-meson production in heavy ion collisions, and (4) $J/Psi$ dissociation in a nuclear medium. In addition, results for the near-threshold $omega$- and $phi$-meson productions in proton proton collisions are reported.