Numerical simulations of strongly correlated electron systems suffer from the notorious fermion sign problem which has prevented progress in understanding if systems like the Hubbard model display high-temperature superconductivity. Here we show how the fermion sign problem can be solved completely with meron-cluster methods in a large class of models of strongly correlated electron systems, some of which are in the extended Hubbard model family and show s-wave superconductivity. In these models we also find that on-site repulsion can even coexist with a weak chemical potential without introducing sign problems. We argue that since these models can be simulated efficiently using cluster algorithms they are ideal for studying many of the interesting phenomena in strongly correlated electron systems.