We present new elemental abundance studies of seven damped Lyman-alpha systems (DLAs). Together with the four DLAs analyzed in Dessauges-Zavadsky et al. (2004), we have a sample of eleven DLA galaxies with uniquely comprehensive and homogeneous abundance measurements. These observations allow one to study the abundance patterns of 22 elements and the chemical variations in the interstellar medium of galaxies outside the Local Group. Comparing the gas-phase abundance ratios of these high redshift galaxies, we found that they show low RMS dispersions, reaching only up 2-3 times the statistical errors for the majority of elements. This uniformity is remarkable given that the quasar sightlines cross gaseous regions with HI column densities spanning over one order of magnitude and metallicities ranging from 1/55 to 1/5 solar. The gas-phase abundance patterns of interstellar medium clouds within the DLA galaxies detected along the velocity profiles show, on the other hand, a high dispersion in several abundance ratios, indicating that chemical variations seem to be more confined to individual clouds within the DLA galaxies than to integrated profiles. The analysis of the cloud-to-cloud chemical variations within seven individual DLAs reveals that five of them show statistically significant variations, higher than 0.2 dex at more than 3 sigma. The sources of these variations are both the differential dust depletion and/or ionization effects; however, no evidence for variations due to different star formation histories could be highlighted. These observations place large constraints on the mixing timescales of protogalaxies and on scenarios of galaxy formation within the CDM hierarchical theory. Finally, we provide an astrophysical determination of the oscillator strength of the NiII 1317 transition.
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