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Register a new userA Machine Learning Framework for Automatic Prediction of Human Semen Motility
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Sandra Ottl
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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In the field of reproductive health, a vital aspect for the detection of male fertility issues is the analysis of human semen quality. Two factors of importance are the morphology and motility of the sperm cells. While the former describes defects in different parts of a spermatozoon, the latter measures the efficient movement of cells. For many non-human species, so-called Computer-Aided Sperm Analysis systems work well for assessing these characteristics from microscopic video recordings but struggle with human sperm samples which generally show higher degrees of debris and dead spermatozoa, as well as lower overall sperm motility. Here, machine learning methods that harness large amounts of training data to extract salient features could support physicians with the detection of fertility issues or in vitro fertilisation procedures. In this work, the overall motility of given sperm samples is predicted with the help of a machine learning framework integrating unsupervised methods for feature extraction with downstream regression models. The models evaluated herein improve on the state-of-the-art for video-based sperm-motility prediction.
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Machine learning has recently been widely adopted to address the managerial decision making problems, in which the decision maker needs to be able to interpret the contributions of individual attributes in an explicit form. However, there is a trade-off between performance and interpretability. Full complexity models are non-traceable black-box, whereas classic interpretable models are usually simplified with lower accuracy. This trade-off limits the application of state-of-the-art machine learning models in management problems, which requires high prediction performance, as well as the understanding of individual attributes contributions to the model outcome. Multiple criteria decision aiding (MCDA) is a family of analytic approaches to depicting the rationale of human decision. It is also limited by strong assumptions. To meet the decision makers demand for more interpretable machine learning models, we propose a novel hybrid method, namely Neural Network-based Multiple Criteria Decision Aiding, which combines an additive value model and a fully-connected multilayer perceptron (MLP) to achieve good performance while capturing the explicit relationships between individual attributes and the prediction. NN-MCDA has a linear component to characterize such relationships through providing explicit marginal value functions, and a nonlinear component to capture the implicit high-order interactions between attributes and their complex nonlinear transformations. We demonstrate the effectiveness of NN-MCDA with extensive simulation studies and three real-world datasets. To the best of our knowledge, this research is the first to enhance the interpretability of machine learning models with MCDA techniques. The proposed framework also sheds light on how to use machine learning techniques to free MCDA from strong assumptions.
What makes a task relatively more or less difficult for a machine compared to a human? Much AI/ML research has focused on expanding the range of tasks that machines can do, with a focus on whether machines can beat humans. Allowing for differences in scale, we can seek interesting (anomalous) pairs of tasks T, T. We define interesting in this way: The harder to learn relation is reversed when comparing human intelligence (HI) to AI. While humans seems to be able to understand problems by formulating rules, ML using neural networks does not rely on constructing rules. We discuss a novel approach where the challenge is to perform well under rules that have been created by human beings. We suggest that this provides a rigorous and precise pathway for understanding the difference between the two kinds of learning. Specifically, we suggest a large and extensible class of learning tasks, formulated as learning under rules. With these tasks, both the AI and HI will be studied with rigor and precision. The immediate goal is to find interesting groundtruth rule pairs. In the long term, the goal will be to understand, in a generalizable way, what distinguishes interesting pairs from ordinary pairs, and to define saliency behind interesting pairs. This may open new ways of thinking about AI, and provide unexpected insights into human learning.
Temporal relational data, perhaps the most commonly used data type in industrial machine learning applications, needs labor-intensive feature engineering and data analyzing for giving precise model predictions. An automatic machine learning framework is needed to ease the manual efforts in fine-tuning the models so that the experts can focus more on other problems that really need humans engagement such as problem definition, deployment, and business services. However, there are three main challenges for building automatic solutions for temporal relational data: 1) how to effectively and automatically mining useful information from the multiple tables and the relations from them? 2) how to be self-adjustable to control the time and memory consumption within a certain budget? and 3) how to give generic solutions to a wide range of tasks? In this work, we propose our solution that successfully addresses the above issues in an end-to-end automatic way. The proposed framework, AutoSmart, is the winning solution to the KDD Cup 2019 of the AutoML Track, which is one of the largest AutoML competition to date (860 teams with around 4,955 submissions). The framework includes automatic data processing, table merging, feature engineering, and model tuning, with a time&memory controller for efficiently and automatically formulating the models. The proposed framework outperforms the baseline solution significantly on several datasets in various domains.
We introduce Ivy, a templated Deep Learning (DL) framework which abstracts existing DL frameworks. Ivy unifies the core functions of these frameworks to exhibit consistent call signatures, syntax and input-output behaviour. New high-level framework-agnostic functions and classes, which are usable alongside framework-specific code, can then be implemented as compositions of the unified low-level Ivy functions. Ivy currently supports TensorFlow, PyTorch, MXNet, Jax and NumPy. We also release four pure-Ivy libraries for mechanics, 3D vision, robotics, and differentiable environments. Through our evaluations, we show that Ivy can significantly reduce lines of code with a runtime overhead of less than 1% in most cases. We welcome developers to join the Ivy community by writing their own functions, layers and libraries in Ivy, maximizing their audience and helping to accelerate DL research through inter-framework codebases. More information can be found at https://ivy-dl.org.
Predicting the evolution of the brain network, also called connectome, by foreseeing changes in the connectivity weights linking pairs of anatomical regions makes it possible to spot connectivity-related neurological disorders in earlier stages and detect the development of potential connectomic anomalies. Remarkably, such a challenging prediction problem remains least explored in the predictive connectomics literature. It is a known fact that machine learning (ML) methods have proven their predictive abilities in a wide variety of computer vision problems. However, ML techniques specifically tailored for the prediction of brain connectivity evolution trajectory from a single timepoint are almost absent. To fill this gap, we organized a Kaggle competition where 20 competing teams designed advanced machine learning pipelines for predicting the brain connectivity evolution from a single timepoint. The competing teams developed their ML pipelines with a combination of data pre-processing, dimensionality reduction, and learning methods. Utilizing an inclusive evaluation approach, we ranked the methods based on two complementary evaluation metrics (mean absolute error (MAE) and Pearson Correlation Coefficient (PCC)) and their performances using different training and testing data perturbation strategies (single random split and cross-validation). The final rank was calculated using the rank product for each competing team across all evaluation measures and validation strategies. In support of open science, the developed 20 ML pipelines along with the connectomic dataset are made available on GitHub. The outcomes of this competition are anticipated to lead to the further development of predictive models that can foresee the evolution of brain connectivity over time, as well as other types of networks (e.g., genetic networks).
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