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In recent years, self-supervised denoising methods have shown impressive performance, which circumvent painstaking collection procedure of noisy-clean image pairs in supervised denoising methods and boost denoising applicability in real world. One of well-known self-supervised denoising strategies is the blind-spot training scheme. However, a few works attempt to improve blind-spot based self-denoiser in the aspect of network architecture. In this paper, we take an intuitive view of blind-spot strategy and consider its process of using neighbor pixels to predict manipulated pixels as an inpainting process. Therefore, we propose a novel Mask Guided Residual Convolution (MGRConv) into common convolutional neural networks, e.g. U-Net, to promote blind-spot based denoising. Our MGRConv can be regarded as soft partial convolution and find a trade-off among partial convolution, learnable attention maps, and gated convolution. It enables dynamic mask learning with appropriate mask constrain. Different from partial convolution and gated convolution, it provides moderate freedom for network learning. It also avoids leveraging external learnable parameters for mask activation, unlike learnable attention maps. The experiments show that our proposed plug-and-play MGRConv can assist blind-spot based denoising network to reach promising results on both existing single-image based and dataset-based methods.
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Purpose: To develop an improved self-supervised learning strategy that efficiently uses the acquired data for training a physics-guided reconstruction network without a database of fully-sampled data. Methods: Currently self-supervised learning for physics-guided reconstruction networks splits acquired undersampled data into two disjoint sets, where one is used for data consistency (DC) in the unrolled network and the other to define the training loss. The proposed multi-mask self-supervised learning via data undersampling (SSDU) splits acquired measurements into multiple pairs of disjoint sets for each training sample, while using one of these sets for DC units and the other for defining loss, thereby more efficiently using the undersampled data. Multi-mask SSDU is applied on fully-sampled 3D knee and prospectively undersampled 3D brain MRI datasets, which are retrospectively subsampled to acceleration rate (R)=8, and compared to CG-SENSE and single-mask SSDU DL-MRI, as well as supervised DL-MRI when fully-sampled data is available. Results: Results on knee MRI show that the proposed multi-mask SSDU outperforms SSDU and performs closely with supervised DL-MRI, while significantly outperforming CG-SENSE. A clinical reader study further ranks the multi-mask SSDU higher than supervised DL-MRI in terms of SNR and aliasing artifacts. Results on brain MRI show that multi-mask SSDU achieves better reconstruction quality compared to SSDU and CG-SENSE. Reader study demonstrates that multi-mask SSDU at R=8 significantly improves reconstruction compared to single-mask SSDU at R=8, as well as CG-SENSE at R=2. Conclusion: The proposed multi-mask SSDU approach enables improved training of physics-guided neural networks without fully-sampled data, by enabling efficient use of the undersampled data with multiple masks.
Recovering a high-quality image from noisy indirect measurements is an important problem with many applications. For such inverse problems, supervised deep convolutional neural network (CNN)-based denoising methods have shown strong results, but the success of these supervised methods critically depends on the availability of a high-quality training dataset of similar measurements. For image denoising, methods are available that enable training without a separate training dataset by assuming that the noise in two different pixels is uncorrelated. However, this assumption does not hold for inverse problems, resulting in artifacts in the denoised images produced by existing methods. Here, we propose Noise2Inverse, a deep CNN-based denoising method for linear image reconstruction algorithms that does not require any additional clean or noisy data. Training a CNN-based denoiser is enabled by exploiting the noise model to compute multiple statistically independent reconstructions. We develop a theoretical framework which shows that such training indeed obtains a denoising CNN, assuming the measured noise is element-wise independent and zero-mean. On simulated CT datasets, Noise2Inverse demonstrates an improvement in peak signal-to-noise ratio and structural similarity index compared to state-of-the-art image denoising methods and conventional reconstruction methods, such as Total-Variation Minimization. We also demonstrate that the method is able to significantly reduce noise in challenging real-world experimental datasets.
Image denoising is of great importance for medical imaging system, since it can improve image quality for disease diagnosis and downstream image analyses. In a variety of applications, dynamic imaging techniques are utilized to capture the time-varying features of the subject, where multiple images are acquired for the same subject at different time points. Although signal-to-noise ratio of each time frame is usually limited by the short acquisition time, the correlation among different time frames can be exploited to improve denoising results with shared information across time frames. With the success of neural networks in computer vision, supervised deep learning methods show prominent performance in single-image denoising, which rely on large datasets with clean-vs-noisy image pairs. Recently, several self-supervised deep denoising models have been proposed, achieving promising results without needing the pairwise ground truth of clean images. In the field of multi-image denoising, however, very few works have been done on extracting correlated information from multiple slices for denoising using self-supervised deep learning methods. In this work, we propose Deformed2Self, an end-to-end self-supervised deep learning framework for dynamic imaging denoising. It combines single-image and multi-image denoising to improve image quality and use a spatial transformer network to model motion between different slices. Further, it only requires a single noisy image with a few auxiliary observations at different time frames for training and inference. Evaluations on phantom and in vivo data with different noise statistics show that our method has comparable performance to other state-of-the-art unsupervised or self-supervised denoising methods and outperforms under high noise levels.
Deep learning based image denoising methods have been recently popular due to their improved performance. Traditionally, these methods are trained in a supervised manner, requiring a set of noisy input and clean target image pairs. More recently, self-supervised approaches have been proposed to learn denoising from only noisy images. These methods assume that noise across pixels is statistically independent, and the underlying image pixels show spatial correlations across neighborhoods. These methods rely on a masking approach that divides the image pixels into two disjoint sets, where one is used as input to the network while the other is used to define the loss. However, these previous self-supervised approaches rely on a purely data-driven regularization neural network without explicitly taking the masking model into account. In this work, building on these self-supervised approaches, we introduce Noise2Inpaint (N2I), a training approach that recasts the denoising problem into a regularized image inpainting framework. This allows us to use an objective function, which can incorporate different statistical properties of the noise as needed. We use algorithm unrolling to unroll an iterative optimization for solving this objective function and train the unrolled network end-to-end. The training paradigm follows the masking approach from previous works, splitting the pixels into two disjoint sets. Importantly, one of these is now used to impose data fidelity in the unrolled network, while the other still defines the loss. We demonstrate that N2I performs successful denoising on real-world datasets, while better preserving details compared to its purely data-driven counterpart Noise2Self.
Deep neural networks have been widely used in image denoising during the past few years. Even though they achieve great success on this problem, they are computationally inefficient which makes them inappropriate to be implemented in mobile devices. In this paper, we propose an efficient deep neural network for image denoising based on pixel-wise classification. Despite using a computationally efficient network cannot effectively remove the noises from any content, it is still capable to denoise from a specific type of pattern or texture. The proposed method follows such a divide and conquer scheme. We first use an efficient U-net to pixel-wisely classify pixels in the noisy image based on the local gradient statistics. Then we replace part of the convolution layers in existing denoising networks by the proposed Class Specific Convolution layers (CSConv) which use different weights for different classes of pixels. Quantitative and qualitative evaluations on public datasets demonstrate that the proposed method can reduce the computational costs without sacrificing the performance compared to state-of-the-art algorithms.
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