The well-known process algebras, such as CCS, ACP and $pi$-calculus, capture the interleaving concurrency based on bisimilarity semantics. We did some work on truly concurrent process algebras, such as CTC, APTC and $pi_{tc}$, capture the true concurrency based on truly concurrent bisimilarities, such as pomset bisimilarity, step bisimilarity, history-preserving (hp-) bisimilarity and hereditary history-preserving (hhp-) bisimilarity. Truly concurrent process algebras are generalizations of the corresponding traditional process algebras. In this book, we introduce reversibility, probabilism, and guards into truly concurrent calculus $pi_{tc}$.