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Register a new userA Decoupled Uncertainty Model for MRI Segmentation Quality Estimation
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Quality control (QC) of MR images is essential to ensure that downstream analyses such as segmentation can be performed successfully. Currently, QC is predominantly performed visually and subjectively, at significant time and operator cost. We aim to automate the process using a probabilistic network that estimates segmentation uncertainty through a heteroscedastic noise model, providing a measure of task-specific quality. By augmenting training images with k-space artefacts, we propose a novel CNN architecture to decouple sources of uncertainty related to the task and different k-space artefacts in a self-supervised manner. This enables the prediction of separate uncertainties for different types of data degradation. While the uncertainty predictions reflect the presence and severity of artefacts, the network provides more robust and generalisable segmentation predictions given the quality of the data. We show that models trained with artefact augmentation provide informative measures of uncertainty on both simulated artefacts and problematic real-world images identified by human raters, both qualitatively and quantitatively in the form of error bars on volume measurements. Relating artefact uncertainty to segmentation Dice scores, we observe that our uncertainty predictions provide a better estimate of MRI quality from the point of view of the task (gray matter segmentation) compared to commonly used metrics of quality including signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), hence providing a real-time quality metric indicative of segmentation quality.
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In recent years, convolutional neural networks have demonstrated promising performance in a variety of medical image segmentation tasks. However, when a trained segmentation model is deployed into the real clinical world, the model may not perform optimally. A major challenge is the potential poor-quality segmentations generated due to degraded image quality or domain shift issues. There is a timely need to develop an automated quality control method that can detect poor segmentations and feedback to clinicians. Here we propose a novel deep generative model-based framework for quality control of cardiac MRI segmentation. It first learns a manifold of good-quality image-segmentation pairs using a generative model. The quality of a given test segmentation is then assessed by evaluating the difference from its projection onto the good-quality manifold. In particular, the projection is refined through iterative search in the latent space. The proposed method achieves high prediction accuracy on two publicly available cardiac MRI datasets. Moreover, it shows better generalisation ability than traditional regression-based methods. Our approach provides a real-time and model-agnostic quality control for cardiac MRI segmentation, which has the potential to be integrated into clinical image analysis workflows.
Quality control (QC) in medical image analysis is time-consuming and laborious, leading to increased interest in automated methods. However, what is deemed suitable quality for algorithmic processing may be different from human-perceived measures of visual quality. In this work, we pose MR image quality assessment from an image reconstruction perspective. We train Bayesian CNNs using a heteroscedastic uncertainty model to recover clean images from noisy data, providing measures of uncertainty over the predictions. This framework enables us to divide data corruption into learnable and non-learnable components and leads us to interpret the predictive uncertainty as an estimation of the achievable recovery of an image. Thus, we argue that quality control for visual assessment cannot be equated to quality control for algorithmic processing. We validate this statement in a multi-task experiment combining artefact recovery with uncertainty prediction and grey matter segmentation. Recognising this distinction between visual and algorithmic quality has the impact that, depending on the downstream task, less data can be excluded based on ``visual quality reasons alone.
Medical image segmentation has significantly benefitted thanks to deep learning architectures. Furthermore, semi-supervised learning (SSL) has recently been a growing trend for improving a models overall performance by leveraging abundant unlabeled data. Moreover, learning multiple tasks within the same model further improves model generalizability. To generate smoother and accurate segmentation masks from 3D cardiac MR images, we present a Multi-task Cross-task learning consistency approach to enforce the correlation between the pixel-level (segmentation) and the geometric-level (distance map) tasks. Our extensive experimentation with varied quantities of labeled data in the training sets justifies the effectiveness of our model for the segmentation of the left atrial cavity from Gadolinium-enhanced magnetic resonance (GE-MR) images. With the incorporation of uncertainty estimates to detect failures in the segmentation masks generated by CNNs, our study further showcases the potential of our model to flag low-quality segmentation from a given model.
We present a deep learning strategy that enables, for the first time, contrast-agnostic semantic segmentation of completely unpreprocessed brain MRI scans, without requiring additional training or fine-tuning for new modalities. Classical Bayesian methods address this segmentation problem with unsupervised intensity models, but require significant computational resources. In contrast, learning-based methods can be fast at test time, but are sensitive to the data available at training. Our proposed learning method, SynthSeg, leverages a set of training segmentations (no intensity images required) to generate synthetic sample images of widely varying contrasts on the fly during training. These samples are produced using the generative model of the classical Bayesian segmentation framework, with randomly sampled parameters for appearance, deformation, noise, and bias field. Because each mini-batch has a different synthetic contrast, the final network is not biased towards any MRI contrast. We comprehensively evaluate our approach on four datasets comprising over 1,000 subjects and four types of MR contrast. The results show that our approach successfully segments every contrast in the data, performing slightly better than classical Bayesian segmentation, and three orders of magnitude faster. Moreover, even within the same type of MRI contrast, our strategy generalizes significantly better across datasets, compared to training using real images. Finally, we find that synthesizing a broad range of contrasts, even if unrealistic, increases the generalization of the neural network. Our code and model are open source at https://github.com/BBillot/SynthSeg.
Deep learning methods have reached state-of-the-art performance in cardiac image segmentation. Currently, the main bottleneck towards their effective translation into clinics requires assuring continuous high model performance and segmentation results. In this work, we present a novel learning framework to monitor the performance of heart segmentation models in the absence of ground truth. Formulated as an anomaly detection problem, the monitoring framework allows deriving surrogate quality measures for a segmentation and allows flagging suspicious results. We propose two different types of quality measures, a global score and a pixel-wise map. We demonstrate their use by reproducing the final rankings of a cardiac segmentation challenge in the absence of ground truth. Results show that our framework is accurate, fast, and scalable, confirming it is a viable option for quality control monitoring in clinical practice and large population studies.
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