We study the effectiveness of the numerical bootstrap techniques recently developed in arXiv:2004.10212 for quantum mechanical systems. We find that for a double well potential the bootstrap method correctly captures non-perturbative aspects. Using this technique we then investigate quantum mechanical potentials related by supersymmetry and recover the expected spectra. Finally, we also study the singlet sector of O(N) vector model quantum mechanics, where we find that the bootstrap method yields results which in the large N agree with saddle point analysis.