In this paper, we give a complete study on the existence and non-existence of normalized solutions for Schr{o}dinger system with quadratic and cubic interactions. In the one dimension case, the energy functional is bounded from below on the product of $L^2$-spheres, normalized ground states exist and are obtained as global minimizers. When $N=2$, the energy functional is not always bounded on the product of $L^2$-spheres. We give a classification of the existence and nonexistence of global minimizers. Then under suitable conditions on $b_1$ and $b_2$, we prove the existence of normalized solutions. When $N=3$, the energy functional is always unbounded on the product of $L^2$-spheres. We show that under suitable conditions on $b_1$ and $b_2$, at least two normalized solutions exist, one is a ground state and the other is an excited state. Furthermore, by refining the upper bound of the ground state energy, we provide a precise mass collapse behavior of the ground state and a precise limit behavior of the excited state as $betarightarrow 0$. Finally, we deal with the high dimensional cases $Ngeq 4$. Several non-existence results are obtained if $beta<0$. When $N=4$, $beta>0$, the system is a mass-energy double critical problem, we obtain the existence of a normalized ground state and its synchronized mass collapse behavior. Comparing with the well studied homogeneous case $beta=0$, our main results indicate that the quadratic interaction term not only enriches the set of solutions to the above Schr{o}dinger system but also leads to a stabilization of the related evolution system.