Purpose: To develop a model to generate volumetric dose distribution from two isodose surfaces (iso-surfaces), and to interactively tune dose distribution by iso-surface dragging. Methods: We model volumetric dose distribution as analytical extension of two iso-surfaces with the extension variables as distances to iso-surfaces. We built a 3D lookup table (LUT) which are generated based on clinical dose distributions. Two LUT tables store the mean and standard deviation of voxel dose values of clinical doses and binned as distance to 100% iso-surface, reference iso-surface and reference dose level. The process of interactive tuning starts from a given base plan. A user drags iso-surface for a desired carving. Our method responds with tuned dose. The derivation of tuned dose follows two steps. Dose is extended from the two user-desired iso-surfaces (eg.100% and 50%) to the whole patient volume by table lookup, using distances to two iso-surfaces and reference dose level as keys. Then we fine tune the extended dose by a correction strategy utilizing the information of base plan. Results: We validated this method on coplanar VMAT doses of post-operative prostate plans. The LUT was populated by dose distributions of 27 clinical plans. We optimized two plans with different rectum sparing for an independent case to mimic the process of dose tuning. The plan with less rectum sparing is set as base plan. The 50% iso-surface of the more-sparing plan is defined as the desired iso-surface input. The dose output by our method (expansion and correction) agrees with the more-sparing plan obtained by optimization, in terms of gamma (97.2%), DVH and profiles. The overall dose reconstruction time is within two seconds. Conclusion: We developed a distance-to-isosurface based volumetric dose reconstruction method, and applied it to interactive tuning with iso-surface dragging.
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