An automorphism of a graph is called quasi-semiregular if it fixes a unique vertex of the graph and its remaining cycles have the same length. This kind of symmetry of graphs was first investigated by Kutnar, Malniv{c}, Mart{i}nez and Maruv{s}iv{c} in 2013, as a generalization of the well-known semiregular automorphism of a graph. Symmetric graphs of valency three or four, admitting a quasi-semiregular automorphism, have been classified in recent two papers. Let $pgeq 5$ be a prime and $Gamma$ a connected symmetric graph of valency $p$ admitting a quasi-semiregular automorphism. In this paper, we first prove that either $Gamma$ is a connected Cayley graph $rm{Cay}(M,S)$ such that $M$ is a $2$-group admitting a fixed-point-free automorphism of order $p$ with $S$ as an orbit of involutions, or $Gamma$ is a normal $N$-cover of a $T$-arc-transitive graph of valency $p$ admitting a quasi-semiregular automorphism, where $T$ is a non-abelian simple group and $N$ is a nilpotent group. Then in case $p=5$, we give a complete classification of such graphs $Gamma$ such that either $rm{Aut}(Gamma)$ has a solvable arc-transitive subgroup or $Gamma$ is $T$-arc-transitive with $T$ a non-abelian simple group. We also construct the first infinite family of symmetric graphs that have a quasi-semiregular automorphism and an insolvable full automorphism group.
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