Within a Bayesian statistical framework using the standard Skyrme-Hartree-Fcok model, the maximum a posteriori (MAP) values and uncertainties of nuclear matter incompressibility and isovector interaction parameters are inferred from the experimental data of giant resonances and neutron-skin thicknesses of typical heavy nuclei. With the uncertainties of the isovector interaction parameters constrained by the data of the isovector giant dipole resonance and the neutron-skin thickness, we have obtained $K_0 = 223_{-8}^{+7}$ MeV at 68% confidence level using the data of the isoscalar giant monopole resonance in $^{208}$Pb measured at the Research Center for Nuclear Physics (RCNP), Japan, and at the Texas A&M University (TAMU), USA. Although the corresponding $^{120}$Sn data gives a MAP value for $K_0$ about 5 MeV smaller than the $^{208}$Pb data, there are significant overlaps in their posterior probability distribution functions.