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Register a new userRECIST-Net: Lesion detection via grouping keypoints on RECIST-based annotation
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Added by
Dong Wei
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Universal lesion detection in computed tomography (CT) images is an important yet challenging task due to the large variations in lesion type, size, shape, and appearance. Considering that data in clinical routine (such as the DeepLesion dataset) are usually annotated with a long and a short diameter according to the standard of Response Evaluation Criteria in Solid Tumors (RECIST) diameters, we propose RECIST-Net, a new approach to lesion detection in which the four extreme points and center point of the RECIST diameters are detected. By detecting a lesion as keypoints, we provide a more conceptually straightforward formulation for detection, and overcome several drawbacks (e.g., requiring extensive effort in designing data-appropriate anchors and losing shape information) of existing bounding-box-based methods while exploring a single-task, one-stage approach compared to other RECIST-based approaches. Experiments show that RECIST-Net achieves a sensitivity of 92.49% at four false positives per image, outperforming other recent methods including those using multi-task learning.
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In clinical trials, one of the radiologists routine work is to measure tumor sizes on medical images using the RECIST criteria (Response Evaluation Criteria In Solid Tumors). However, manual measurement is tedious and subject to inter-observer variability. We propose a unified framework named SEENet for semi-automatic lesion textit{SE}gmentation and RECIST textit{E}stimation on a variety of lesions over the entire human body. The user is only required to provide simple guidance by clicking once near the lesion. SEENet consists of two main parts. The first one extracts the lesion of interest with the one-click guidance, roughly segments the lesion, and estimates its RECIST measurement. Based on the results of the first network, the second one refines the lesion segmentation and RECIST estimation. SEENet achieves state-of-the-art performance in lesion segmentation and RECIST estimation on the large-scale public DeepLesion dataset. It offers a practical tool for radiologists to generate reliable lesion measurements (i.e. segmentation mask and RECIST) with minimal human effort and greatly reduced time.
Measuring lesion size is an important step to assess tumor growth and monitor disease progression and therapy response in oncology image analysis. Although it is tedious and highly time-consuming, radiologists have to work on this task by using RECIST criteria (Response Evaluation Criteria In Solid Tumors) routinely and manually. Even though lesion segmentation may be the more accurate and clinically more valuable means, physicians can not manually segment lesions as now since much more heavy laboring will be required. In this paper, we present a prior-guided dual-path network (PDNet) to segment common types of lesions throughout the whole body and predict their RECIST diameters accurately and automatically. Similar to [1], a click guidance from radiologists is the only requirement. There are two key characteristics in PDNet: 1) Learning lesion-specific attention matrices in parallel from the click prior information by the proposed prior encoder, named click-driven attention; 2) Aggregating the extracted multi-scale features comprehensively by introducing top-down and bottom-up connections in the proposed decoder, named dual-path connection. Experiments show the superiority of our proposed PDNet in lesion segmentation and RECIST diameter prediction using the DeepLesion dataset and an external test set. PDNet learns comprehensive and representative deep image features for our tasks and produces more accurate results on both lesion segmentation and RECIST diameter prediction.
Response evaluation criteria in solid tumors (RECIST) is the standard measurement for tumor extent to evaluate treatment responses in cancer patients. As such, RECIST annotations must be accurate. However, RECIST annotations manually labeled by radiologists require professional knowledge and are time-consuming, subjective, and prone to inconsistency among different observers. To alleviate these problems, we propose a cascaded convolutional neural network based method to semi-automatically label RECIST annotations and drastically reduce annotation time. The proposed method consists of two stages: lesion region normalization and RECIST estimation. We employ the spatial transformer network (STN) for lesion region normalization, where a localization network is designed to predict the lesion region and the transformation parameters with a multi-task learning strategy. For RECIST estimation, we adapt the stacked hourglass network (SHN), introducing a relationship constraint loss to improve the estimation precision. STN and SHN can both be learned in an end-to-end fashion. We train our system on the DeepLesion dataset, obtaining a consensus model trained on RECIST annotations performed by multiple radiologists over a multi-year period. Importantly, when judged against the inter-reader variability of two additional radiologist raters, our system performs more stably and with less variability, suggesting that RECIST annotations can be reliably obtained with reduced labor and time.
Since the PointNet was proposed, deep learning on point cloud has been the concentration of intense 3D research. However, existing point-based methods usually are not adequate to extract the local features and the spatial pattern of a point cloud for further shape understanding. This paper presents an end-to-end framework, SK-Net, to jointly optimize the inference of spatial keypoint with the learning of feature representation of a point cloud for a specific point cloud task. One key process of SK-Net is the generation of spatial keypoints (Skeypoints). It is jointly conducted by two proposed regulating losses and a task objective function without knowledge of Skeypoint location annotations and proposals. Specifically, our Skeypoints are not sensitive to the location consistency but are acutely aware of shape. Another key process of SK-Net is the extraction of the local structure of Skeypoints (detail feature) and the local spatial pattern of normalized Skeypoints (pattern feature). This process generates a comprehensive representation, pattern-detail (PD) feature, which comprises the local detail information of a point cloud and reveals its spatial pattern through the part district reconstruction on normalized Skeypoints. Consequently, our network is prompted to effectively understand the correlation between different regions of a point cloud and integrate contextual information of the point cloud. In point cloud tasks, such as classification and segmentation, our proposed method performs better than or comparable with the state-of-the-art approaches. We also present an ablation study to demonstrate the advantages of SK-Net.
Breast lesion detection in ultrasound video is critical for computer-aided diagnosis. However, detecting lesion in video is quite challenging due to the blurred lesion boundary, high similarity to soft tissue and lack of video annotations. In this paper, we propose a semi-supervised breast lesion detection method based on temporal coherence which can detect the lesion more accurately. We aggregate features extracted from the historical key frames with adaptive key-frame scheduling strategy. Our proposed method accomplishes the unlabeled videos detection task by leveraging the supervision information from a different set of labeled images. In addition, a new WarpNet is designed to replace both the traditional spatial warping and feature aggregation operation, leading to a tremendous increase in speed. Experiments on 1,060 2D ultrasound sequences demonstrate that our proposed method achieves state-of-the-art video detection result as 91.3% in mean average precision and 19 ms per frame on GPU, compared to a RetinaNet based detection method in 86.6% and 32 ms.
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