The main purpose of this paper is to establish the existence, nonexistence and symmetry of nontrivial solutions to the higher order Brezis-Nirenberg problems associated with the GJMS operators $P_k$ on bounded domains in the hyperbolic space $mathbb{H}^n$ and as well as on the entire hyperbolic space $mathbb{H}^n$. Among other techniques, one of our main novelties is to use crucially the Helgason-Fourier analysis on hyperbolic spaces and the higher order Hardy-Sobolev-Mazya inequalities and careful study of delicate properties of Greens functions of $P_k-lambda$ on hyperbolic spaces which are of independent interests in dealing with such problems. Such Greens functions allow us to obtain the integral representations of solutions and thus to avoid using the maximum principle to establish the symmetry of solutions.
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