Many dynamical phenomena, e.g., pathogen transmission, disruptions in transport over networks, and (fake) news purveyance, concern spreading that plays out on top of networks with changing architectures over time - commonly known as temporal networks. Assessing a systems proneness to facilitate spreading phenomena, which we refer to as its spreading vulnerability, from its topological information alone remains a challenging task. We report a methodological advance in terms of a novel metric for topological complexity: entanglement entropy. Using publicly available datasets, we demonstrate that the metric naturally allows for topological comparisons across vastly different systems, and importantly, reveals that the spreading vulnerability of a system can be quantitatively related to its topological complexity. In doing so, the metric opens itself for applications in a wide variety of natural, social, biological and engineered systems.
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