We present measurements of the electron helicity asymmetry in quasi-elastic proton knockout from $^{2}$H and $^{12}$C nuclei by polarized electrons. This asymmetry depends on the fifth structure function, is antisymmetric with respect to the scattering plane, and vanishes in the absence of final-state interactions, and thus it provides a sensitive tool for their study. Our kinematics cover the full range in off-coplanarity angle $phi_{pq}$, with a polar angle $theta_{pq}$ coverage up to about 8 degrees. The missing energy resolution enabled us to determine the asymmetries for knock-out resulting in different states of the residual $^{11}$B system. We find that the helicity asymmetry for $p$-shell knockout from $^{12}$C depends on the final state of the residual system and is relatively large (up to $approx 0.16$), especially at low missing momentum. It is considerably smaller (up to $approx 0.01$) for $s$-shell knockout from both $^{12}$C and $^2$H. The data for $^2$H are in very good agreement with theoretical calculations, while the predictions for $^{12}$C exhibit differences with respect to the data.
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