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For collecting high-quality high-resolution (HR) MR image, we propose a novel image reconstruction network named IREM, which is trained on multiple low-resolution (LR) MR images and achieve an arbitrary up-sampling rate for HR image reconstruction. In this work, we suppose the desired HR image as an implicit continuous function of the 3D image spatial coordinate and the thick-slice LR images as several sparse discrete samplings of this function. Then the super-resolution (SR) task is to learn the continuous volumetric function from a limited observations using an fully-connected neural network combined with Fourier feature positional encoding. By simply minimizing the error between the network prediction and the acquired LR image intensity across each imaging plane, IREM is trained to represent a continuous model of the observed tissue anatomy. Experimental results indicate that IREM succeeds in representing high frequency image feature, and in real scene data collection, IREM reduces scan time and achieves high-quality high-resolution MR imaging in terms of SNR and local image detail.
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Image reconstruction is an inverse problem that solves for a computational image based on sampled sensor measurement. Sparsely sampled image reconstruction poses addition challenges due to limited measurements. In this work, we propose an implicit Neural Representation learning methodology with Prior embedding (NeRP) to reconstruct a computational image from sparsely sampled measurements. The method differs fundamentally from previous deep learning-based image reconstruction approaches in that NeRP exploits the internal information in an image prior, and the physics of the sparsely sampled measurements to produce a representation of the unknown subject. No large-scale data is required to train the NeRP except for a prior image and sparsely sampled measurements. In addition, we demonstrate that NeRP is a general methodology that generalizes to different imaging modalities such as CT and MRI. We also show that NeRP can robustly capture the subtle yet significant image changes required for assessing tumor progression.
Recent works have demonstrated that deep learning (DL) based compressed sensing (CS) implementation can accelerate Magnetic Resonance (MR) Imaging by reconstructing MR images from sub-sampled k-space data. However, network architectures adopted in previous methods are all designed by handcraft. Neural Architecture Search (NAS) algorithms can automatically build neural network architectures which have outperformed human designed ones in several vision tasks. Inspired by this, here we proposed a novel and efficient network for the MR image reconstruction problem via NAS instead of manual attempts. Particularly, a specific cell structure, which was integrated into the model-driven MR reconstruction pipeline, was automatically searched from a flexible pre-defined operation search space in a differentiable manner. Experimental results show that our searched network can produce better reconstruction results compared to previous state-of-the-art methods in terms of PSNR and SSIM with 4-6 times fewer computation resources. Extensive experiments were conducted to analyze how hyper-parameters affect reconstruction performance and the searched structures. The generalizability of the searched architecture was also evaluated on different organ MR datasets. Our proposed method can reach a better trade-off between computation cost and reconstruction performance for MR reconstruction problem with good generalizability and offer insights to design neural networks for other medical image applications. The evaluation code will be available at https://github.com/yjump/NAS-for-CSMRI.
Gadolinium-based contrast agents (GBCAs) have been widely used to better visualize disease in brain magnetic resonance imaging (MRI). However, gadolinium deposition within the brain and body has raised safety concerns about the use of GBCAs. Therefore, the development of novel approaches that can decrease or even eliminate GBCA exposure while providing similar contrast information would be of significant use clinically. For brain tumor patients, standard-of-care includes repeated MRI with gadolinium-based contrast for disease monitoring, increasing the risk of gadolinium deposition. In this work, we present a deep learning based approach for contrast-enhanced T1 synthesis on brain tumor patients. A 3D high-resolution fully convolutional network (FCN), which maintains high resolution information through processing and aggregates multi-scale information in parallel, is designed to map pre-contrast MRI sequences to contrast-enhanced MRI sequences. Specifically, three pre-contrast MRI sequences, T1, T2 and apparent diffusion coefficient map (ADC), are utilized as inputs and the post-contrast T1 sequences are utilized as target output. To alleviate the data imbalance problem between normal tissues and the tumor regions, we introduce a local loss to improve the contribution of the tumor regions, which leads to better enhancement results on tumors. Extensive quantitative and visual assessments are performed, with our proposed model achieving a PSNR of 28.24dB in the brain and 21.2dB in tumor regions. Our results suggests the potential of substituting GBCAs with synthetic contrast images generated via deep learning.
We explore an ensembled $Sigma$-net for fast parallel MR imaging, including parallel coil networks, which perform implicit coil weighting, and sensitivity networks, involving explicit sensitivity maps. The networks in $Sigma$-net are trained in a supervised way, including content and GAN losses, and with various ways of data consistency, i.e., proximal mappings, gradient descent and variable splitting. A semi-supervised finetuning scheme allows us to adapt to the k-space data at test time, which, however, decreases the quantitative metrics, although generating the visually most textured and sharp images. For this challenge, we focused on robust and high SSIM scores, which we achieved by ensembling all models to a $Sigma$-net.
Magnetic resonance (MR) image acquisition is an inherently prolonged process, whose acceleration by obtaining multiple undersampled images simultaneously through parallel imaging has always been the subject of research. In this paper, we propose the Dual-Octave Convolution (Dual-OctConv), which is capable of learning multi-scale spatial-frequency features from both real and imaginary components, for fast parallel MR image reconstruction. By reformulating the complex operations using octave convolutions, our model shows a strong ability to capture richer representations of MR images, while at the same time greatly reducing the spatial redundancy. More specifically, the input feature maps and convolutional kernels are first split into two components (i.e., real and imaginary), which are then divided into four groups according to their spatial frequencies. Then, our Dual-OctConv conducts intra-group information updating and inter-group information exchange to aggregate the contextual information across different groups. Our framework provides two appealing benefits: (i) it encourages interactions between real and imaginary components at various spatial frequencies to achieve richer representational capacity, and (ii) it enlarges the receptive field by learning multiple spatial-frequency features of both the real and imaginary components. We evaluate the performance of the proposed model on the acceleration of multi-coil MR image reconstruction. Extensive experiments are conducted on an {in vivo} knee dataset under different undersampling patterns and acceleration factors. The experimental results demonstrate the superiority of our model in accelerated parallel MR image reconstruction. Our code is available at: github.com/chunmeifeng/Dual-OctConv.
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