The TARK conference (Theoretical Aspects of Rationality and Knowledge) is a biannual conference that aims to bring together researchers from a wide variety of fields, including computer science, artificial intelligence, game theory, decision theory, philosophy, logic, linguistics, and cognitive science. Its goal is to further our understanding of interdisciplinary issues involving reasoning about rationality and knowledge. Topics of interest include, but are not limited to, semantic models for knowledge, belief, awareness and uncertainty, bounded rationality and resource-bounded reasoning, commonsense epistemic reasoning, epistemic logic, epistemic game theory, knowledge and action, applications of reasoning about knowledge and other mental states, belief revision, and foundations of multi-agent systems. These proceedings contain the papers that have been accepted for presentation at the Eighteenth Conference on Theoretical Aspects of Rationality and Knowledge (TARK 2021), held between June 25 and June 27, 2021, at Tsinghua University at Beijing, China.