No Arabic abstract
There are many approaches that use weak-supervision to train networks to segment 2D images. By contrast, existing 3D approaches rely on full-supervision of a subset of 2D slices of the 3D image volume. In this paper, we propose an approach that is truly weakly-supervised in the sense that we only need to provide a sparse set of 3D point on the surface of target objects, an easy task that can be quickly done. We use the 3D points to deform a 3D template so that it roughly matches the target object outlines and we introduce an architecture that exploits the supervision provided by coarse template to train a network to find accurate boundaries. We evaluate the performance of our approach on Computed Tomography (CT), Magnetic Resonance Imagery (MRI) and Electron Microscopy (EM) image datasets. We will show that it outperforms a more traditional approach to weak-supervision in 3D at a reduced supervision cost.
Medical image annotation is a major hurdle for developing precise and robust machine learning models. Annotation is expensive, time-consuming, and often requires expert knowledge, particularly in the medical field. Here, we suggest using minimal user interaction in the form of extreme point clicks to train a segmentation model which, in effect, can be used to speed up medical image annotation. An initial segmentation is generated based on the extreme points utilizing the random walker algorithm. This initial segmentation is then used as a noisy supervision signal to train a fully convolutional network that can segment the organ of interest, based on the provided user clicks. Through experimentation on several medical imaging datasets, we show that the predictions of the network can be refined using several rounds of training with the prediction from the same weakly annotated data. Further improvements are shown utilizing the clicked points within a custom-designed loss and attention mechanism. Our approach has the potential to speed up the process of generating new training datasets for the development of new machine learning and deep learning-based models for, but not exclusively, medical image analysis.
This paper studies the problem of learning semantic segmentation from image-level supervision only. Current popular solutions leverage object localization maps from classifiers as supervision signals, and struggle to make the localization maps capture more complete object content. Rather than previous efforts that primarily focus on intra-image information, we address the value of cross-image semantic relations for comprehensive object pattern mining. To achieve this, two neural co-attentions are incorporated into the classifier to complimentarily capture cross-image semantic similarities and differences. In particular, given a pair of training images, one co-attention enforces the classifier to recognize the common semantics from co-attentive objects, while the other one, called contrastive co-attention, drives the classifier to identify the unshared semantics from the rest, uncommon objects. This helps the classifier discover more object patterns and better ground semantics in image regions. In addition to boosting object pattern learning, the co-attention can leverage context from other related images to improve localization map inference, hence eventually benefiting semantic segmentation learning. More essentially, our algorithm provides a unified framework that handles well different WSSS settings, i.e., learning WSSS with (1) precise image-level supervision only, (2) extra simple single-label data, and (3) extra noisy web data. It sets new state-of-the-arts on all these settings, demonstrating well its efficacy and generalizability. Moreover, our approach ranked 1st place in the Weakly-Supervised Semantic Segmentation Track of CVPR2020 Learning from Imperfect Data Challenge.
Weakly supervised image segmentation trained with image-level labels usually suffers from inaccurate coverage of object areas during the generation of the pseudo groundtruth. This is because the object activation maps are trained with the classification objective and lack the ability to generalize. To improve the generality of the objective activation maps, we propose a region prototypical network RPNet to explore the cross-image object diversity of the training set. Similar object parts across images are identified via region feature comparison. Object confidence is propagated between regions to discover new object areas while background regions are suppressed. Experiments show that the proposed method generates more complete and accurate pseudo object masks, while achieving state-of-the-art performance on PASCAL VOC 2012 and MS COCO. In addition, we investigate the robustness of the proposed method on reduced training sets.
Automated segmentation in medical image analysis is a challenging task that requires a large amount of manually labeled data. However, manually annotating medical data is often laborious, and most existing learning-based approaches fail to accurately delineate object boundaries without effective geometric constraints. Contrastive learning, a sub-area of self-supervised learning, has recently been noted as a promising direction in multiple application fields. In this work, we present a novel Contrastive Voxel-wise Representation Learning (CVRL) method with geometric constraints to learn global-local visual representations for volumetric medical image segmentation with limited annotations. Our framework can effectively learn global and local features by capturing 3D spatial context and rich anatomical information. Specifically, we introduce a voxel-to-volume contrastive algorithm to learn global information from 3D images, and propose to perform local voxel-to-voxel contrast to explicitly make use of local cues in the embedding space. Moreover, we integrate an elastic interaction-based active contour model as a geometric regularization term to enable fast and reliable object delineations in an end-to-end learning manner. Results on the Atrial Segmentation Challenge dataset demonstrate superiority of our proposed scheme, especially in a setting with a very limited number of annotated data.
We propose adversarial constrained-CNN loss, a new paradigm of constrained-CNN loss methods, for weakly supervised medical image segmentation. In the new paradigm, prior knowledge is encoded and depicted by reference masks, and is further employed to impose constraints on segmentation outputs through adversarial learning with reference masks. Unlike pseudo label methods for weakly supervised segmentation, such reference masks are used to train a discriminator rather than a segmentation network, and thus are not required to be paired with specific images. Our new paradigm not only greatly facilitates imposing prior knowledge on networks outputs, but also provides stronger and higher-order constraints, i.e., distribution approximation, through adversarial learning. Extensive experiments involving different medical modalities, different anatomical structures, different topologies of the object of interest, different levels of prior knowledge and weakly supervised annotations with different annotation ratios is conducted to evaluate our ACCL method. Consistently superior segmentation results over the size constrained-CNN loss method have been achieved, some of which are close to the results of full supervision, thus fully verifying the effectiveness and generalization of our method. Specifically, we report an average Dice score of 75.4% with an average annotation ratio of 0.65%, surpassing the prior art, i.e., the size constrained-CNN loss method, by a large margin of 11.4%. Our codes are made publicly available at https://github.com/PengyiZhang/ACCL.