We point out that light gauge boson mediators could induce new interference effects in neutrino-electron scattering that can be used to enhance the sensitivity of neutrino-flavor-selective high-intensity neutrino experiments, such as DUNE. We particularly emphasize a destructive interference effect, leading to a deficit between the Standard Model expectation and the experimental measurement of the differential cross-sections, which is prominent only in either the neutrino or the antineutrino mode, depending on the mediator couplings. Therefore, the individual neutrino (or antineutrino) mode could allow for sensitivity reaches superior to the combined analysis, and moreover, could distinguish between different types of gauge boson mediators.
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