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Register a new userLearn Fine-grained Adaptive Loss for Multiple Anatomical Landmark Detection in Medical Images
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Added by
Juzheng Miao
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Automatic and accurate detection of anatomical landmarks is an essential operation in medical image analysis with a multitude of applications. Recent deep learning methods have improved results by directly encoding the appearance of the captured anatomy with the likelihood maps (i.e., heatmaps). However, most current solutions overlook another essence of heatmap regression, the objective metric for regressing target heatmaps and rely on hand-crafted heuristics to set the target precision, thus being usually cumbersome and task-specific. In this paper, we propose a novel learning-to-learn framework for landmark detection to optimize the neural network and the target precision simultaneously. The pivot of this work is to leverage the reinforcement learning (RL) framework to search objective metrics for regressing multiple heatmaps dynamically during the training process, thus avoiding setting problem-specific target precision. We also introduce an early-stop strategy for active termination of the RL agents interaction that adapts the optimal precision for separate targets considering exploration-exploitation tradeoffs. This approach shows better stability in training and improved localization accuracy in inference. Extensive experimental results on two different applications of landmark localization: 1) our in-house prenatal ultrasound (US) dataset and 2) the publicly available dataset of cephalometric X-Ray landmark detection, demonstrate the effectiveness of our proposed method. Our proposed framework is general and shows the potential to improve the efficiency of anatomical landmark detection.
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Recently, there is an increasing demand for automatically detecting anatomical landmarks which provide rich structural information to facilitate subsequent medical image analysis. Current methods related to this task often leverage the power of deep neural networks, while a major challenge in fine tuning such models in medical applications arises from insufficient number of labeled samples. To address this, we propose to regularize the knowledge transfer across source and target tasks through cross-task representation learning. The proposed method is demonstrated for extracting facial anatomical landmarks which facilitate the diagnosis of fetal alcohol syndrome. The source and target tasks in this work are face recognition and landmark detection, respectively. The main idea of the proposed method is to retain the feature representations of the source model on the target task data, and to leverage them as an additional source of supervisory signals for regularizing the target model learning, thereby improving its performance under limited training samples. Concretely, we present two approaches for the proposed representation learning by constraining either final or intermediate model features on the target model. Experimental results on a clinical face image dataset demonstrate that the proposed approach works well with few labeled data, and outperforms other compared approaches.
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Landmark localization plays an important role in medical image analysis. Learning based methods, including CNN and GCN, have demonstrated the state-of-the-art performance. However, most of these methods are fully-supervised and heavily rely on manual labeling of a large training dataset. In this paper, based on a fully-supervised graph-based method, DAG, we proposed a semi-supervised extension of it, termed few-shot DAG, ie five-shot DAG. It first trains a DAG model on the labeled data and then fine-tunes the pre-trained model on the unlabeled data with a teacher-student SSL mechanism. In addition to the semi-supervised loss, we propose another loss using JS divergence to regulate the consistency of the intermediate feature maps. We extensively evaluated our method on pelvis, hand and chest landmark detection tasks. Our experiment results demonstrate consistent and significant improvements over previous methods.
Facial landmark detection aims to localize the anatomically defined points of human faces. In this paper, we study facial landmark detection from partially labeled facial images. A typical approach is to (1) train a detector on the labeled images; (2) generate new training samples using this detectors prediction as pseudo labels of unlabeled images; (3) retrain the detector on the labeled samples and partial pseudo labeled samples. In this way, the detector can learn from both labeled and unlabeled data to become robust. In this paper, we propose an interaction mechanism between a teacher and two students to generate more reliable pseudo labels for unlabeled data, which are beneficial to semi-supervised facial landmark detection. Specifically, the two students are instantiated as dual detectors. The teacher learns to judge the quality of the pseudo labels generated by the students and filter out unqualified samples before the retraining stage. In this way, the student detectors get feedback from their teacher and are retrained by premium data generated by itself. Since the two students are trained by different samples, a combination of their predictions will be more robust as the final prediction compared to either prediction. Extensive experiments on 300-W and AFLW benchmarks show that the interactions between teacher and students contribute to better utilization of the unlabeled data and achieves state-of-the-art performance.
Colonoscopy is a standard imaging tool for visualizing the entire gastrointestinal (GI) tract of patients to capture lesion areas. However, it takes the clinicians excessive time to review a large number of images extracted from colonoscopy videos. Thus, automatic detection of biological anatomical landmarks within the colon is highly demanded, which can help reduce the burden of clinicians by providing guidance information for the locations of lesion areas. In this article, we propose a novel deep learning-based approach to detect biological anatomical landmarks in colonoscopy videos. First, raw colonoscopy video sequences are pre-processed to reject interference frames. Second, a ResNet-101 based network is used to detect three biological anatomical landmarks separately to obtain the intermediate detection results. Third, to achieve more reliable localization of the landmark periods within the whole video period, we propose to post-process the intermediate detection results by identifying the incorrectly predicted frames based on their temporal distribution and reassigning them back to the correct class. Finally, the average detection accuracy reaches 99.75%. Meanwhile, the average IoU of 0.91 shows a high degree of similarity between our predicted landmark periods and ground truth. The experimental results demonstrate that our proposed model is capable of accurately detecting and localizing biological anatomical landmarks from colonoscopy videos.
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