We have studied in the mechanical and chemical instabilities as well as the liquid-gas phase transition in isospin asymmetric quark matter based on the NJL and the pNJL model. Areas of the mechanical instability region and the liquid-gas coexistence region are seen to be enlarged with a larger quark matter symmetry energy or in the presence of strange quarks. Our study shows that the light cluster yield ratio observed in relativistic heavy-ion collisions may not be affected much by the uncertainties of the isospin effect, while the hadron-quark phase transition in compact stars as well as their mergers is likely to be a smooth one.
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