This paper aims at providing multi-source remote sensing images registered in geometric space for image fusion. Focusing on the characteristics and differences of multi-source remote sensing images, a feature-based registration algorithm is implemented. The key technologies include image scale-space for implementing multi-scale properties, Harris corner detection for keypoints extraction, and partial intensity invariant feature descriptor (PIIFD) for keypoints description. Eventually, a multi-scale Harris-PIIFD image registration algorithm framework is proposed. The experimental results of four sets of representative real data show that the algorithm has excellent, stable performance in multi-source remote sensing image registration, and can achieve accurate spatial alignment, which has strong practical application value and certain generalization ability.