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Tracking Cells and their Lineages via Labeled Random Finite Sets

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 Publication date 2021
and research's language is English




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Determining the trajectories of cells and their lineages or ancestries in live-cell experiments are fundamental to the understanding of how cells behave and divide. This paper proposes novel online algorithms for jointly tracking and resolving lineages of an unknown and time-varying number of cells from time-lapse video data. Our approach involves modeling the cell ensemble as a labeled random finite set with labels representing cell identities and lineages. A spawning model is developed to take into account cell lineages and changes in cell appearance prior to division. We then derive analytic filters to propagate multi-object distributions that contain information on the current cell ensemble including their lineages. We also develop numerical implementations of the resulting multi-object filters. Experiments using simulation, synthetic cell migration video, and real time-lapse sequence, are presented to demonstrate the capability of the solutions.



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This paper proposes an on-line multiple object tracking algorithm that can operate in unknown background. In a majority of multiple object tracking applications, model parameters for background processes such as clutter and detection are unknown and vary with time, hence the ability of the algorithm to adaptively learn the these parameters is essential in practice. In this work, we detail how the Generalized Labeled Multi Bernouli (GLMB) filter a tractable and provably Bayes optimal multi-object tracker can be tailored to learn clutter and detection parameters on the fly while tracking. Provided that these background model parameters do not fluctuate rapidly compared to the data rate, the proposed algorithm can adapt to the unknown background yielding better tracking performance.
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