We carry out a test of the cosmic distance duality relation using a sample of 52 SPT-SZ clusters, along with X-ray measurements from XMM-Newton. To carry out this test, we need an estimate of the luminosity distance ($D_L$) at the redshift of the cluster. For this purpose, we use three independent methods: directly using $D_L$ from the closest Type Ia Supernovae from the Union 2.1 sample, non-parametric reconstruction of $D_L$ using the same Union 2.1 sample, and finally using $H(z)$ measurements from cosmic chronometers and reconstructing $D_L$ using Gaussian Process regression. We use four different functions to characterize the deviations from CDDR. All our results for these ($4 times 3$) analyses are consistent with CDDR to within 1$sigma$.