Direct evidence of micro-turbulence effect on the onset of neoclassical tearing mode (NTM) is reported for the first time in this letter. A puzzling positive correlation between critical width of seed island of NTM and normalized plasma pressure beta_p is first observed employing a novel method for clearly separating the processes of seed island and the onset of NTM in the EAST tokamak. Different from the methods developed before, the width of the seed island is well controlled by slowly ramping up the current in resonant magnetic perturbation coils. It is revealed that the positive correlation is mainly attributed to the enhancement of perpendicular transport by micro-turbulence, which overcomes the destabilizing effect of beta_p on the onset of NTM. Reduced magnetohydrodynamics (MHD) modeling well reproduced the two states of nonlinear bifurcations observed in this experiment by including the finite transport effect. This result provides a new route for understanding multi-scale interaction in plasma physics.
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