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Register a new userInformation-based Disentangled Representation Learning for Unsupervised MR Harmonization
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Accuracy and consistency are two key factors in computer-assisted magnetic resonance (MR) image analysis. However, contrast variation from site to site caused by lack of standardization in MR acquisition impedes consistent measurements. In recent years, image harmonization approaches have been proposed to compensate for contrast variation in MR images. Current harmonization approaches either require cross-site traveling subjects for supervised training or heavily rely on site-specific harmonization models to encourage harmonization accuracy. These requirements potentially limit the application of current harmonization methods in large-scale multi-site studies. In this work, we propose an unsupervised MR harmonization framework, CALAMITI (Contrast Anatomy Learning and Analysis for MR Intensity Translation and Integration), based on information bottleneck theory. CALAMITI learns a disentangled latent space using a unified structure for multi-site harmonization without the need for traveling subjects. Our model is also able to adapt itself to harmonize MR images from a new site with fine tuning solely on images from the new site. Both qualitative and quantitative results show that the proposed method achieves superior performance compared with other unsupervised harmonization approaches.
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Humans learn to imitate by observing others. However, robot imitation learning generally requires expert demonstrations in the first-person view (FPV). Collecting such FPV videos for every robot could be very expensive. Third-person imitation learning (TPIL) is the concept of learning action policies by observing other agents in a third-person view (TPV), similar to what humans do. This ultimately allows utilizing human and robot demonstration videos in TPV from many different data sources, for the policy learning. In this paper, we present a TPIL approach for robot tasks with egomotion. Although many robot tasks with ground/aerial mobility often involve actions with camera egomotion, study on TPIL for such tasks has been limited. Here, FPV and TPV observations are visually very different; FPV shows egomotion while the agent appearance is only observable in TPV. To enable better state learning for TPIL, we propose our disentangled representation learning method. We use a dual auto-encoder structure plus representation permutation loss and time-contrastive loss to ensure the state and viewpoint representations are well disentangled. Our experiments show the effectiveness of our approach.
We propose a novel unsupervised generative model that learns to disentangle object identity from other low-level aspects in class-imbalanced data. We first investigate the issues surrounding the assumptions about uniformity made by InfoGAN, and demonstrate its ineffectiveness to properly disentangle object identity in imbalanced data. Our key idea is to make the discovery of the discrete latent factor of variation invariant to identity-preserving transformations in real images, and use that as a signal to learn the appropriate latent distribution representing object identity. Experiments on both artificial (MNIST, 3D cars, 3D chairs, ShapeNet) and real-world (YouTube-Faces) imbalanced datasets demonstrate the effectiveness of our method in disentangling object identity as a latent factor of variation.
We present a novel unsupervised domain adaptation method for small bowel segmentation based on feature disentanglement. To make the domain adaptation more controllable, we disentangle intensity and non-intensity features within a unique two-stream auto-encoding architecture, and selectively adapt the non-intensity features that are believed to be more transferable across domains. The segmentation prediction is performed by aggregating the disentangled features. We evaluated our method using intravenous contrast-enhanced abdominal CT scans with and without oral contrast, which are used as source and target domains, respectively. The proposed method showed clear improvements in terms of three different metrics compared to other domain adaptation methods that are without the feature disentanglement. The method brings small bowel segmentation closer to clinical application.
Supervised learning method requires a large volume of annotated datasets. Collecting such datasets is time-consuming and expensive. Until now, very few annotated COVID-19 imaging datasets are available. Although self-supervised learning enables us to bootstrap the training by exploiting unlabeled data, the generic self-supervised methods for natural images do not sufficiently incorporate the context. For medical images, a desirable method should be sensitive enough to detect deviation from normal-appearing tissue of each anatomical region; here, anatomy is the context. We introduce a novel approach with two levels of self-supervised representation learning objectives: one on the regional anatomical level and another on the patient-level. We use graph neural networks to incorporate the relationship between different anatomical regions. The structure of the graph is informed by anatomical correspondences between each patient and an anatomical atlas. In addition, the graph representation has the advantage of handling any arbitrarily sized image in full resolution. Experiments on large-scale Computer Tomography (CT) datasets of lung images show that our approach compares favorably to baseline methods that do not account for the context. We use the learnt embedding to quantify the clinical progression of COVID-19 and show that our method generalizes well to COVID-19 patients from different hospitals. Qualitative results suggest that our model can identify clinically relevant regions in the images.
Purpose: This work proposes a novel approach to efficiently generate MR fingerprints for MR fingerprinting (MRF) problems based on the unsupervised deep learning model generative adversarial networks (GAN). Methods: The GAN model is adopted and modified for better convergence and performance, resulting in an MRF specific model named GAN-MRF. The GAN-MRF model is trained, validated, and tested using different MRF fingerprints simulated from the Bloch equations with certain MRF sequence. The performance and robustness of the model are further tested by using in vivo data collected on a 3 Tesla scanner from a healthy volunteer together with MRF dictionaries with different sizes. T1, T2 maps are generated and compared quantitatively. Results: The validation and testing curves for the GAN-MRF model show no evidence of high bias or high variance problems. The sample MRF fingerprints generated from the trained GAN-MRF model agree well with the benchmark fingerprints simulated from the Bloch equations. The in vivo T1, T2 maps generated from the GAN-MRF fingerprints are in good agreement with those generated from the Bloch simulated fingerprints, showing good performance and robustness of the proposed GAN-MRF model. Moreover, the MRF dictionary generation time is reduced from hours to sub-second for the testing dictionary. Conclusion: The GAN-MRF model enables a fast and accurate generation of the MRF fingerprints. It significantly reduces the MRF dictionary generation process and opens the door for real-time applications and sequence optimization problems.
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