Nonlinear solid friction between the gel matrix and DNA molecules inhibits the motion of DNA during electrophoresis. We report enhanced mobility of the DNA using external noise to alleviate the effect of solid friction. In presence of noise, the mobility of 1 kbp DNA increases ~ 86% compared to the conventional gel electrophoresis, whereas the increment is more than ~113 % for 6 kbp DNA. At low power of the noise, super Arrhenius kinetics suggest the collective behavior of the activated motion of DNA molecules. Stochastic simulation following modified Langevin equation with the asymmetric pore size distribution of the agarose gel successfully predicts the mobility of DNA molecules and estimates the huge frictional force at the DNA-gel matrix interface.
Download