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Register a new userTransfer Learning with Ensembles of Deep Neural Networks for Skin Cancer Detection in Imbalanced Data Sets
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Added by
Aqsa Saeed Qureshi
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Several machine learning techniques for accurate detection of skin cancer from medical images have been reported. Many of these techniques are based on pre-trained convolutional neural networks (CNNs), which enable training the models based on limited amounts of training data. However, the classification accuracy of these models still tends to be severely limited by the scarcity of representative images from malignant tumours. We propose a novel ensemble-based CNN architecture where multiple CNN models, some of which are pre-trained and some are trained only on the data at hand, along with auxiliary data in the form of metadata associated with the input images, are combined using a meta-learner. The proposed approach improves the models ability to handle limited and imbalanced data. We demonstrate the benefits of the proposed technique using a dataset with 33126 dermoscopic images from 2056 patients. We evaluate the performance of the proposed technique in terms of the F1-measure, area under the ROC curve (AUC-ROC), and area under the PR-curve (AUC-PR), and compare it with that of seven different benchmark methods, including two recent CNN-based techniques. The proposed technique compares favourably in terms of all the evaluation metrics.
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Prostate cancer is one of the most common forms of cancer and the third leading cause of cancer death in North America. As an integrated part of computer-aided detection (CAD) tools, diffusion-weighted magnetic resonance imaging (DWI) has been intensively studied for accurate detection of prostate cancer. With deep convolutional neural networks (CNNs) significant success in computer vision tasks such as object detection and segmentation, different CNNs architectures are increasingly investigated in medical imaging research community as promising solutions for designing more accurate CAD tools for cancer detection. In this work, we developed and implemented an automated CNNs-based pipeline for detection of clinically significant prostate cancer (PCa) for a given axial DWI image and for each patient. DWI images of 427 patients were used as the dataset, which contained 175 patients with PCa and 252 healthy patients. To measure the performance of the proposed pipeline, a test set of 108 (out of 427) patients were set aside and not used in the training phase. The proposed pipeline achieved area under the receiver operating characteristic curve (AUC) of 0.87 (95% Confidence Interval (CI): 0.84-0.90) and 0.84 (95% CI: 0.76-0.91) at slice level and patient level, respectively.
In the low-data regime, it is difficult to train good supervised models from scratch. Instead practitioners turn to pre-trained models, leveraging transfer learning. Ensembling is an empirically and theoretically appealing way to construct powerful predictive models, but the predominant approach of training multiple deep networks with different random initialisations collides with the need for transfer via pre-trained weights. In this work, we study different ways of creating ensembles from pre-trained models. We show that the nature of pre-training itself is a performant source of diversity, and propose a practical algorithm that efficiently identifies a subset of pre-trained models for any downstream dataset. The approach is simple: Use nearest-neighbour accuracy to rank pre-trained models, fine-tune the best ones with a small hyperparameter sweep, and greedily construct an ensemble to minimise validation cross-entropy. When evaluated together with strong baselines on 19 different downstream tasks (the Visual Task Adaptation Benchmark), this achieves state-of-the-art performance at a much lower inference budget, even when selecting from over 2,000 pre-trained models. We also assess our ensembles on ImageNet variants and show improved robustness to distribution shift.
In this paper, we propose a new first-order gradient-based algorithm to train deep neural networks. We first introduce the sign operation of stochastic gradients (as in sign-based methods, e.g., SIGN-SGD) into ADAM, which is called as signADAM. Moreover, in order to make the rate of fitting each feature closer, we define a confidence function to distinguish different components of gradients and apply it to our algorithm. It can generate more sparse gradients than existing algorithms do. We call this new algorithm signADAM++. In particular, both our algorithms are easy to implement and can speed up training of various deep neural networks. The motivation of signADAM++ is preferably learning features from the most different samples by updating large and useful gradients regardless of useless information in stochastic gradients. We also establish theoretical convergence guarantees for our algorithms. Empirical results on various datasets and models show that our algorithms yield much better performance than many state-of-the-art algorithms including SIGN-SGD, SIGNUM and ADAM. We also analyze the performance from multiple perspectives including the loss landscape and develop an adaptive method to further improve generalization. The source code is available at https://github.com/DongWanginxdu/signADAM-Learn-by-Confidence.
Wrist Fracture is the most common type of fracture with a high incidence rate. Conventional radiography (i.e. X-ray imaging) is used for wrist fracture detection routinely, but occasionally fracture delineation poses issues and an additional confirmation by computed tomography (CT) is needed for diagnosis. Recent advances in the field of Deep Learning (DL), a subfield of Artificial Intelligence (AI), have shown that wrist fracture detection can be automated using Convolutional Neural Networks. However, previous studies did not pay close attention to the difficult cases which can only be confirmed via CT imaging. In this study, we have developed and analyzed a state-of-the-art DL-based pipeline for wrist (distal radius) fracture detection -- DeepWrist, and evaluated it against one general population test set, and one challenging test set comprising only cases requiring confirmation by CT. Our results reveal that a typical state-of-the-art approach, such as DeepWrist, while having a near-perfect performance on the general independent test set, has a substantially lower performance on the challenging test set -- average precision of 0.99 (0.99-0.99) vs 0.64 (0.46-0.83), respectively. Similarly, the area under the ROC curve was of 0.99 (0.98-0.99) vs 0.84 (0.72-0.93), respectively. Our findings highlight the importance of a meticulous analysis of DL-based models before clinical use, and unearth the need for more challenging settings for testing medical AI systems.
Roof falls due to geological conditions are major safety hazards in mining and tunneling industries, causing lost work times, injuries, and fatalities. Several large-opening limestone mines in the Eastern and Midwestern United States have roof fall problems caused by high horizontal stresses. The typical hazard management approach for this type of roof fall hazard relies heavily on visual inspections and expert knowledge. In this study, we propose an artificial intelligence (AI) based system for the detection roof fall hazards caused by high horizontal stresses. We use images depicting hazardous and non-hazardous roof conditions to develop a convolutional neural network for autonomous detection of hazardous roof conditions. To compensate for limited input data, we utilize a transfer learning approach. In transfer learning, an already-trained network is used as a starting point for classification in a similar domain. Results confirm that this approach works well for classifying roof conditions as hazardous or safe, achieving a statistical accuracy of 86%. However, accuracy alone is not enough to ensure a reliable hazard management system. System constraints and reliability are improved when the features being used by the network are understood. Therefore, we used a deep learning interpretation technique called integrated gradients to identify the important geologic features in each image for prediction. The analysis of integrated gradients shows that the system mimics expert judgment on roof fall hazard detection. The system developed in this paper demonstrates the potential of deep learning in geological hazard management to complement human experts, and likely to become an essential part of autonomous tunneling operations in those cases where hazard identification heavily depends on expert knowledge.
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