We present a quantum synthesis algorithm designed to produce short circuits and to scale well in practice. The main contribution is a novel representation of circuits able to encode placement and topology using generic gates, which allows the QFAST algorithm to replace expensive searches over circuit structures with few steps of numerical optimization. When compared against optimal depth, search based state-of-the-art techniques, QFAST produces comparable results: 1.19x longer circuits up to four qubits, with an increase in compilation speed of 3.6x. In addition, QFAST scales up to seven qubits. When compared with the state-of-the-art rule based decomposition techniques in Qiskit, QFAST produces circuits shorter by up to two orders of magnitude (331x), albeit 5.6x slower. We also demonstrate the composability with other techniques and the tunability of our formulation in terms of circuit depth and running time.
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