Radioisotope $^{52g}$Mn is of special interest for multimodal imaging. Using state-of-art nuclear reaction codes, we study the alternative nuclear reaction route $^{nat}$V($alpha$,x)$^{52g}$Mn in comparison with the standard production routes based upon the use of chromium targets. The integral yields of $^{52g}$Mn and contaminants have been evaluated. The main outcome of this investigation is that the production of the main contaminant isotope $^{54}$Mn is expected to be lower than with $^{nat}$Cr. The study also reveals a large spread in the cross-section data set and points out the need of more precise measurements of the reaction $^{nat}$V($alpha$,x)$^{52g}$Mn as well as the need of a more accurate theoretical description.