Cosmic-ray muons can be used for the non-destructive imaging of spent nuclear fuel in sealed dry storage casks. The scattering data of the muons after traversing provides information on the thereby penetrated materials. Based on these properties, we investigate and discuss the theoretical feasibility of detecting single missing fuel rods in a sealed cask for the first time. We perform simulations of a vertically standing generic cask model loaded with fuel assemblies from a pressurized water reactor and muon detectors placed above and below the cask. By analysing the scattering angles and applying a significance ratio based on the Kolmogorov-Smirnov test statistic we conclude that missing rods can be reliably identified in a reasonable measuring time period depending on their position in the assembly and cask, and on the angular acceptance criterion of the primary, incoming muons.
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