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Register a new userExistence and incompressible limit of a tissue growth model with autophagy
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In this paper we study a cross-diffusion system whose coefficient matrix is non-symmetric and degenerate. The system arises in the study of tissue growth with autophagy. The existence of a weak solution is established. We also investigate the limiting behavior of solutions as the pressure gets stiff. The so-called incompressible limit is a free boundary problem of Hele-Shaw type. Our key new discovery is that the usual energy estimate still holds as long as the time variable stays away from $0$.
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This paper proposes a model for the growth two interacting populations of cells that do not mix. The dynamics is driven by pressure and cohesion forces on the one hand and proliferation on the other hand. Following earlier works on the single population case, we show that the model approximates a free boundary Hele Shaw type model that we characterise using both analytical and numerical arguments.
Both compressible and incompressible porous medium models are used in the literature to describe the mechanical properties of living tissues. These two classes of models can be related using a stiff pressure law. In the incompressible limit, the compressible model generates a free boundary problem of Hele-Shaw type where incompressibility holds in the saturated phase. Here we consider the case with a nutrient. Then, a badly coupled system of equations describes the cell density number and the nutrient concentration. For that reason, the derivation of the free boundary (incompressible) limit was an open problem, in particular a difficulty is to establish the so-called complementarity relation which allows to recover the pressure using an elliptic equation. To establish the limit, we use two new ideas. The first idea, also used recently for related problems, is to extend the usual Aronson-Benilan estimates in $L^infty$ to an $L^2$ setting. The second idea is to derive a sharp uniform $L^4$ estimate on the pressure gradient, independently of space dimension.
In this article we consider viscous flow in the exterior of an obstacle satisfying the standard no-slip boundary condition at the surface of the obstacle. We seek conditions under which solutions of the Navier-Stokes system in the exterior domain converge to solutions of the Euler system in the full space when both viscosity and the size of the obstacle vanish. We prove that this convergence is true assuming two hypothesis: first, that the initial exterior domain velocity converges strongly in $L^2$ to the full-space initial velocity and second, that the diameter of the obstacle is smaller than a suitable constant times viscosity, or, in other words, that the obstacle is sufficiently small. The convergence holds as long as the solution to the limit problem is known to exist and stays sufficiently smooth. This work complements the study of incompressible flow around small obstacles, which has been carried out in [1,2,3] [1] D. Iftimie and J. Kelliher, {it Remarks on the vanishing obstacle limit for a 3D viscous incompressible fluid.} Preprint available at http://math.univ-lyon1.fr/~iftimie/ARTICLES/viscoushrink3d.pdf . [2] D. Iftimie, M. C. Lopes Filho, and H. J. Nussenzveig Lopes. {it Two dimensional incompressible ideal flow around a small obstacle.} Comm. Partial Differential Equations {bf 28} (2003), no. 1-2, 349--379. [3] D. Iftimie, M. C. Lopes Filho, and H. J. Nussenzveig Lopes. {it Two dimensional incompressible viscous flow around a small obstacle.} Math. Ann. {bf 336} (2006), no. 2, 449--489.
The thermalization of a gas towards a Maxwellian velocity distribution with the background temperature is described by a kinetic relaxation model. The sum of the kinetic energy of the gas and the thermal energy of the background are conserved, and the heat flow in the background is governed by the Fourier law. For the coupled nonlinear system of the kinetic and the heat equation, existence of solutions is proved on the one-dimensional torus. Spectral stability of the equilibrium is shown on the torus in arbitrary dimensions by hypocoercivity methods. The macroscopic limit towards a nonlinear cross-diffusion problem is carried out formally.
In this paper, we derive an effective macroscale description suitable to describe the growth of biological tissue within a porous tissue-engineering scaffold. As in our recent work (Holden textit{et al.} A multiphase multiscale model for nutrient limited tissue growth, The ANZIAM Journal, 2018, doi:10.1017/S1446181118000044) the underlying tissue dynamics is described as a multiphase mixture, thereby naturally accommodating features such as interstitial growth and active cell motion. Via a linearisation of the underlying multiphase model (whose nonlinearity poses significant challenge for such analyses), we obtain, by means of multiple-scales homogenisation, a simplified macroscale model that nevertheless retains explicit dependence on both the microscale scaffold structure and the tissue dynamics. The model we obtain comprises Darcy flow, and differential equations for the volume fraction of cells within the scaffold and the concentration of nutrient, required for growth. These are coupled to underlying Stokes-type cell problems that provide permeability tensors to parameterise the macroscale description. In Holden textit{et al.}, the cell problems retain macroscale dependence, posing significant computational challenges; here, we obtain a decoupled system whereby the quasi-steady cell-problems may be solved separately from the macroscale description, thereby greatly reducing the complexity associated with fully-coupled multiscale descriptions. Moreover, we indicate how the formulation is influenced by a set of alternative microscale boundary conditions.S
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