We study a false vacuum decay in a two-dimensional black hole spacetime background. The decay rate in the case that nucleation site locates at a black hole center has been calculated in the literature. We develop a method for calculating the decay rate of the false vacuum for a generic nucleation site. We find that the decay rate becomes larger when the nucleation site is close to the black hole horizon and coincides with that in Minkowski spacetime when the nucleation site goes to infinity.