Global gradient driven GENE gyrokinetic simulations are used to investigate TCV plasmas with negative triangularity. Considering a limited L-mode plasma, corresponding to an experimental triangularity scan, numerical results are able to reproduce the actual transport level over a major fraction of the plasma minor radius for a plasma with $delta_{rm LCFS}=-0.3$ and its equivalent with standard positive triangularity $delta$. For the same heat flux, a larger electron temperature gradient is sustained by $delta<0$, in turn resulting in an improved electron energy confinement. Consistently with the experiments, a reduction of the electron density fluctuations is also seen. Local flux-tube simulations are used to gauge the magnitude of nonlocal effects. Surprisingly, very little differences are found between local and global approaches for $delta>0$, while local results yield a strong overestimation of the heat fluxes when $delta<0$. Despite the high sensitivity of the turbulence level with respect to the input parameters, global effects appear to play a crucial role in the negative triangularity plasma and must be retained to reconcile simulations and experiments. Finally, a general stabilizing effect of negative triangularity, reducing fluxes and fluctuations by a factor dependent on the actual profiles, is recovered.
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