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Register a new userCOVID-19 Prognosis via Self-Supervised Representation Learning and Multi-Image Prediction
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Added by
Anuroop Sriram
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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The rapid spread of COVID-19 cases in recent months has strained hospital resources, making rapid and accurate triage of patients presenting to emergency departments a necessity. Machine learning techniques using clinical data such as chest X-rays have been used to predict which patients are most at risk of deterioration. We consider the task of predicting two types of patient deterioration based on chest X-rays: adverse event deterioration (i.e., transfer to the intensive care unit, intubation, or mortality) and increased oxygen requirements beyond 6 L per day. Due to the relative scarcity of COVID-19 patient data, existing solutions leverage supervised pretraining on related non-COVID images, but this is limited by the differences between the pretraining data and the target COVID-19 patient data. In this paper, we use self-supervised learning based on the momentum contrast (MoCo) method in the pretraining phase to learn more general image representations to use for downstream tasks. We present three results. The first is deterioration prediction from a single image, where our model achieves an area under receiver operating characteristic curve (AUC) of 0.742 for predicting an adverse event within 96 hours (compared to 0.703 with supervised pretraining) and an AUC of 0.765 for predicting oxygen requirements greater than 6 L a day at 24 hours (compared to 0.749 with supervised pretraining). We then propose a new transformer-based architecture that can process sequences of multiple images for prediction and show that this model can achieve an improved AUC of 0.786 for predicting an adverse event at 96 hours and an AUC of 0.848 for predicting mortalities at 96 hours. A small pilot clinical study suggested that the prediction accuracy of our model is comparable to that of experienced radiologists analyzing the same information.
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Ultrasound (US) is a non-invasive yet effective medical diagnostic imaging technique for the COVID-19 global pandemic. However, due to complex feature behaviors and expensive annotations of US images, it is difficult to apply Artificial Intelligence (AI) assisting approaches for lungs multi-symptom (multi-label) classification. To overcome these difficulties, we propose a novel semi-supervised Two-Stream Active Learning (TSAL) method to model complicated features and reduce labeling costs in an iterative procedure. The core component of TSAL is the multi-label learning mechanism, in which label correlations information is used to design multi-label margin (MLM) strategy and confidence validation for automatically selecting informative samples and confident labels. On this basis, a multi-symptom multi-label (MSML) classification network is proposed to learn discriminative features of lung symptoms, and a human-machine interaction is exploited to confirm the final annotations that are used to fine-tune MSML with progressively labeled data. Moreover, a novel lung US dataset named COVID19-LUSMS is built, currently containing 71 clinical patients with 6,836 images sampled from 678 videos. Experimental evaluations show that TSAL using only 20% data can achieve superior performance to the baseline and the state-of-the-art. Qualitatively, visualization of both attention map and sample distribution confirms the good consistency with the clinic knowledge.
The crux of self-supervised video representation learning is to build general features from unlabeled videos. However, most recent works have mainly focused on high-level semantics and neglected lower-level representations and their temporal relationship which are crucial for general video understanding. To address these challenges, this paper proposes a multi-level feature optimization framework to improve the generalization and temporal modeling ability of learned video representations. Concretely, high-level features obtained from naive and prototypical contrastive learning are utilized to build distribution graphs, guiding the process of low-level and mid-level feature learning. We also devise a simple temporal modeling module from multi-level features to enhance motion pattern learning. Experiments demonstrate that multi-level feature optimization with the graph constraint and temporal modeling can greatly improve the representation ability in video understanding. Code is available at https://github.com/shvdiwnkozbw/Video-Representation-via-Multi-level-Optimization.
To take full advantage of fast-growing unlabeled networked data, this paper introduces a novel self-supervised strategy for graph representation learning by exploiting natural supervision provided by the data itself. Inspired by human social behavior, we assume that the global context of each node is composed of all nodes in the graph since two arbitrary entities in a connected network could interact with each other via paths of varying length. Based on this, we investigate whether the global context can be a source of free and effective supervisory signals for learning useful node representations. Specifically, we randomly select pairs of nodes in a graph and train a well-designed neural net to predict the contextual position of one node relative to the other. Our underlying hypothesis is that the representations learned from such within-graph context would capture the global topology of the graph and finely characterize the similarity and differentiation between nodes, which is conducive to various downstream learning tasks. Extensive benchmark experiments including node classification, clustering, and link prediction demonstrate that our approach outperforms many state-of-the-art unsupervised methods and sometimes even exceeds the performance of supervised counterparts.
Anomaly detection in video is a challenging computer vision problem. Due to the lack of anomalous events at training time, anomaly detection requires the design of learning methods without full supervision. In this paper, we approach anomalous event detection in video through self-supervised and multi-task learning at the object level. We first utilize a pre-trained detector to detect objects. Then, we train a 3D convolutional neural network to produce discriminative anomaly-specific information by jointly learning multiple proxy tasks: three self-supervised and one based on knowledge distillation. The self-supervised tasks are: (i) discrimination of forward/backward moving objects (arrow of time), (ii) discrimination of objects in consecutive/intermittent frames (motion irregularity) and (iii) reconstruction of object-specific appearance information. The knowledge distillation task takes into account both classification and detection information, generating large prediction discrepancies between teacher and student models when anomalies occur. To the best of our knowledge, we are the first to approach anomalous event detection in video as a multi-task learning problem, integrating multiple self-supervised and knowledge distillation proxy tasks in a single architecture. Our lightweight architecture outperforms the state-of-the-art methods on three benchmarks: Avenue, ShanghaiTech and UCSD Ped2. Additionally, we perform an ablation study demonstrating the importance of integrating self-supervised learning and normality-specific distillation in a multi-task learning setting.
Recent advances in deep learning have achieved promising performance for medical image analysis, while in most cases ground-truth annotations from human experts are necessary to train the deep model. In practice, such annotations are expensive to collect and can be scarce for medical imaging applications. Therefore, there is significant interest in learning representations from unlabelled raw data. In this paper, we propose a self-supervised learning approach to learn meaningful and transferable representations from medical imaging video without any type of human annotation. We assume that in order to learn such a representation, the model should identify anatomical structures from the unlabelled data. Therefore we force the model to address anatomy-aware tasks with free supervision from the data itself. Specifically, the model is designed to correct the order of a reshuffled video clip and at the same time predict the geometric transformation applied to the video clip. Experiments on fetal ultrasound video show that the proposed approach can effectively learn meaningful and strong representations, which transfer well to downstream tasks like standard plane detection and saliency prediction.
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