The CatWISE2020 Catalog consists of 1,890,715,640 sources over the entire sky selected from WISE and NEOWISE survey data at 3.4 and 4.6 $mu$m (W1 and W2) collected from 2010 Jan. 7 to 2018 Dec. 13. This dataset adds two years to that used for the CatWISE Preliminary Catalog (Eisenhardt et al., 2020), bringing the total to six times as many exposures spanning over sixteen times as large a time baseline as the AllWISE catalog. The other major change from the CatWISE Preliminary Catalog is that the detection list for the CatWISE2020 Catalog was generated using ${it crowdsource}$ (Schlafly et al. 2019), while the CatWISE Preliminary Catalog used the detection software used for AllWISE. These two factors result in roughly twice as many sources in the CatWISE2020 Catalog. The scatter with respect to ${it Spitzer}$ photometry at faint magnitudes in the COSMOS field, which is out of the Galactic plane and at low ecliptic latitude (corresponding to lower WISE coverage depth) is similar to that for the CatWISE Preliminary Catalog. The 90% completeness depth for the CatWISE2020 Catalog is at W1=17.7 mag and W2=17.5 mag, 1.7 mag deeper than in the CatWISE Preliminary Catalog. From comparison to ${it Gaia}$, CatWISE2020 motions are accurate at the 20 mas yr$^{-1}$ level for W1$sim$15 mag sources, and at the $sim100$ mas yr$^{-1}$ level for W1$sim$17 mag sources. This level of precision represents a 12$times$ improvement over AllWISE. The CatWISE catalogs are available in the WISE/NEOWISE Enhanced and Contributed Products area of the NASA/IPAC Infrared Science Archive.