Interacting bosonic particles in artificial lattices have proven to be a powerful tool for the investigation of exotic phases of matter as well as phenomena resulting from non-trivial topology. Exciton-polaritons, bosonic quasi-particles of light and matter, have shown to combine the on-chip benefits of optical systems with strong interactions, inherited form their matter character. Technologically significant semiconductor platforms, however, strictly require cryogenic temperatures for operability. In this paper, we demonstrate exciton-polariton lasing for topological defects emerging form the imprinted lattice structure at room temperature. We utilize a monomeric red fluorescent protein derived from DsRed of Discosoma sea anemones, hosting highly stable Frenkel excitons. Using a patterned mirror cavity, we tune the lattice potential landscape of a linear Su-Schrieffer-Heeger chain to design topological defects at domain boundaries and at the edge. In spectroscopic experiments, we unequivocally demonstrate polariton lasing from these topological defects. This progress promises to be a paradigm shift, paving the road to interacting Boson many-body physics at ambient conditions.
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