The role of non-stoquasticity in the field of quantum annealing and adiabatic quantum computing is an actively debated topic. We study a strongly-frustrated quasi-one-dimensional quantum Ising model on a two-leg ladder to elucidate how a first-order phase transition with a topological origin is affected by interactions of the $pm XX$-type. Such interactions are sometimes known as stoquastic (negative sign) and non-stoquastic (positive sign) catalysts. Carrying out a symmetry-preserving real-space renormalization group analysis and extensive density-matrix renormalization group computations, we show that the phase diagrams obtained by these two methods are in qualitative agreement with each other and reveal that the first-order quantum phase transition of a topological nature remains stable against the introduction of both $XX$-type catalysts. This is the first study of the effects of non-stoquasticity on a first-order phase transition between topologically distinct phases. Our results indicate that non-stoquastic catalysts are generally insufficient for removing topological obstacles in quantum annealing and adiabatic quantum computing.
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